Imatinib Suppresses Cryoglobulinemia and Secondary Membranoproliferative Glomerulonephritis
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چکیده
منابع مشابه
Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
Imatinib is a receptor tyrosine kinase inhibitor that blocks the activity of c-Abl, c-Kit, and PDGF receptors. We tested the protective effects of imatinib in thymic stromal lymphopoietin transgenic mice, a model of cryoglobulinemia and associated membranoproliferative glomerulonephritis (MPGN), in which some glomerular manifestations likely result from PDGF receptor activation. Surprising, adm...
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BACKGROUND AND OBJECTIVES Membranoproliferative glomerulonephritis (MPGN) is an immune complex-mediated glomerulonephritis characterized by subendothelial and mesangial deposition of immune complexes. Autoimmune diseases and chronic infections, such as hepatitis C, are commonly recognized causes of MPGN; however, monoclonal gammopathy is a less widely recognized cause of MPGN. DESIGN, SETTING...
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Membranoproliferative glomerulonephritis (MPGN) refers to glomerular pathology in which there is thickening of the capillary wall together with mesangial expansion. In this article we firstly review the pathological features of MPGN and discuss how advances in our understanding of the association between abnormalities in the regulation of complement and MPGN have revealed limitations in the his...
متن کاملMembranoproliferative glomerulonephritis.
Glomerulonephritis (GN) encompasses a wide variety of primary and secondary diseases that cause injury to the functioning unit of the kidney, the glomerulus. The many classifications of GN sometimes lead to confusion. This case study describes an individual with membranoproliferative GN and includes discussion of classification, treatment, and prognosis of this disease.
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gal thyroiditis caused by Aspergillus. Blood vessels were invaded by the hyphae of the fungus (Figure 1). A culture of the aspirated fluid showed no growth. The results of repeated tests with an Aspergillus antigen (galactomannan) enzyme-linked immunosorbent assay (ELISA) were negative. There was no evidence of aspergillosis in the other organs. Blood and sputum cultures were negative. Intraven...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2008
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2008010036